This is an updated version of an earlier concept.
Forgotten Realms: A Days Of Future Past-style dark future in which Lolth has devoured all but a handful of her fellow deities, leaving only a few of the most interesting to hide and wonder when it will be their turn. Lolth's dominance has is unkind. She has spun a sun-occluding cocoon around the entirety of Faerun, plunging the world into gloomy twilight. With her blessing, spiders evolve into ever more capable predators, filling ever larger portions of ecosystems. The magical Weave, the source of magic itself, is pulled taught and patterned like a web, twining around Drowish prayers and filling them with power. A spectral web stretches across the afterlife, snaring souls before they can reach their final rest and filling an already bloated Lolth with even more power.
Non-drow or anybody that dislikes eating fungus and spiders is pretty unhappy. A few remaining deities and their followers prowl the shadows, surviving as best they can and seeking a way to defeat or escape Lolth.